Key result
The hand-mounted JoStent was equivalent to the premounted Multi-Link Duet stent for late lumen loss at 1 year.
Why the study?
Does the hand-mounted JoStent provide equivalent late lumen loss compared to the premounted Multi-Link Duet stent in patients with coronary artery disease?
RCT (n=505)
randomly assigned
Yes
Does the hand-mounted JoStent provide equivalent late lumen loss compared to the premounted Multi-Link Duet stent in patients with coronary artery disease?
The hand-mounted JoStent and premounted Multi-Link Duet stent provide equivalent 1-year angiographic and clinical outcomes in patients with coronary artery disease.
Answers are grounded in this paper and cite their sources.
Supports hand-mounted JoStent as equivalent alternative in PCI; confirms angiographic equivalence to premounted stents.
The objective of this multicenter randomized study was to compare the angiographic and clinical results achieved 1 year after coronary placement of two stent models: the hand-mounted JoStent and the premounted Multi-Link Duet stent. We included 505 patients who were randomly assigned to receive either the hand-mounted JoStent (n = 252) or the premounted Multi-Link Duet stent (n = 253). The primary endpoint of the study, late lumen loss, measured 1.12 mm in the JoStent group and 1.17 mm in the Multi-Link Duet group. These values were statistically equivalent (P = 0.02 from the equivalence test). No significant difference was observed in the incidence of restenosis, 24.2% in the JoStent and 25.2% in the Multi-Link Duet stent group, and target vessel revascularization, 13.9% in the JoStent and 15.4% in the Multi-Link Duet patients. In conclusion, the hand-mounted JoStent and the premounted Multi-Link Duet stent enable excellent procedural success rates and equally favorable 1-year angiographic and clinical outcomes.
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Mehilli et al. (2001) conducted an RCT in coronary artery disease (n=505). hand-mounted JoStent vs. premounted Multi-Link Duet stent was evaluated on late lumen loss (p=0.02 from the equivalence test). The hand-mounted JoStent was equivalent to the premounted Multi-Link Duet stent for late lumen loss at 1 year.
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