Population
Transfected HEK cells and heart extracts
Comparison
Nedd4-2 coexpression/cotransfection vs Catalytically inactive Nedd4-2, Nedd4-1 isoform…
Design
Preclinical
Authors
Loading...
Nedd4-2 reduces Nav1.5 density via PY motif; hypothesis-generating for ubiquitin effects on cardiac excitability.
The ubiquitin-protein ligase Nedd4-2 regulates the cardiac sodium channel Nav1.5 by decreasing its density at the cell surface.
Bemmelen et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: