Key result
A digital computer program was designed to calculate physiological dead space, cardiac output, and venous admixture based on the rebreathing method for mixed venous PCO2 without cardiac catheter data.
The development of a digital computer program automates complex exercise physiology calculations, reducing time and human error while eliminating the need for invasive cardiac catheter data.
May enable non-invasive cardiopulmonary calculations during exercise; leaves open prospective validation before clinical adoption.
Calculations of the results of respiratory and cardiac function studies such as the physiological dead space, cardiac output and venous admixture are time consuming and very susceptible to human error. A digital computer program has been designed to perform these calculations based on the rebreathing method for mixed venous PCO₂ so that cardiac catheter data is not required. The conversion of CO₂ differences to content differences is described and the disturbances of the CO₂dissociation curve which may occur are discussed and allowed for in the program. Particular attention is given to the graphical ‘bloodless’ solution where arterial PCO₂ is unknown and the program has been designed to print or draw the possible relationships between dead space, cardiac output and arterial PCO₂ under these circumstances. The derivation of all equations are given and the scope and versatility of the actual program is outlined.
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S. Godfrey (2009) studied Respiratory and cardiac function studies. Digital computer program for exercise physiology calculations was evaluated. A digital computer program was designed to calculate physiological dead space, cardiac output, and venous admixture based on the rebreathing method for mixed venous PCO2 without cardiac catheter data.
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