Key result
Indirect Fick CO2 rebreathing matches thermodilution for resting cardiac output accuracy with ~5-10% reproducibility.
Why the study?
The accuracy and reproducibility of the non-invasive CO2 rebreathing method for measuring resting cardiac output compared to thermodilution were evaluated.
Does the indirect Fick CO2 rebreathing method accurately measure resting cardiac output compared to thermodilution in human subjects?
Comparison
Indirect Fick CO2 rebreathing method vs thermodilution method
Design
Comparative study using three alternative calculation methods for veno-arterial CO2 content difference
Authors
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Supports non-invasive resting CO measurement in select patients; leaves open need for larger validation before broader adoption.
Cross-Sectional (n=11)
Does the indirect Fick CO2 rebreathing method accurately measure resting cardiac output compared to thermodilution in human subjects?
The indirect Fick CO2 rebreathing method is an accurate, non-invasive alternative to thermodilution for measuring resting cardiac output in normal subjects and those with cardiovascular disease.
Hargreaves et al. (1983) conducted a cross-sectional in Cardiac and pulmonary disease (n=11). Indirect Fick (CO2 rebreathing method) vs. Thermodilution method was evaluated on Resting cardiac output measurement reproducibility and correlation. The indirect Fick CO2 rebreathing method accurately measured resting cardiac output with 5-10% reproducibility, comparable to the thermodilution method.
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