Key result
Age is the major independent factor affecting left ventricular filling in normal subjects, explaining up to 61% of the variance in the peak E/peak A ratio.
Cross-Sectional (n=189)
Age is the primary independent determinant of left ventricular filling parameters measured by Doppler echocardiography in healthy individuals.
Age adjustment essential for E/A interpretation in normals; leaves open validation and outcome relevance in disease.
Pulsed Doppler measurements of left ventricular filling (LVF), two-dimensional and M-mode echocardiograms were performed in 189 healthy subjects, in order to evaluate factors influencing LVF Doppler indexes in normal subjects. LVF Doppler indexes (peak E, peak A, peak E/peak A, deceleration rate of peak E (ED) were related by univariate and multivariate analyses with the following parameters: age, sex, heart rate, systolic and diastolic blood pressure, aortic root and left atrial dimensions, left ventricular mass index, left ventricular shortening fraction. The stepwise analysis showed that age by itself explained up to 18% of peak E variance, 50% of peak A variance, 61% of peak E/peak A variance and 25% of ED variance. The other variables entered into the regression, slightly improved the predictive power (less than 10%). In conclusion, age is the major independent factor affecting LVF in normal subjects, although other variables show significant correlation also after age adjustment.
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Manca et al. (2008) conducted a cross-sectional in Healthy subjects (n=189). Age was evaluated on Variance in left ventricular filling Doppler indexes (peak E, peak A, peak E/peak A, deceleration rate of peak E). Age is the major independent factor affecting left ventricular filling in normal subjects, explaining up to 61% of the variance in the peak E/peak A ratio.
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