March 1, 1983Journal of Cardiovascular Pharmacology
Quinine and Quinidine
Why the study?
Does quinidine cause greater QT prolongation compared to quinine in patients treated for Plasmodium falciparum malaria?
Population
45 patients being treated for Plasmodium falciparum malaria (n=31 receiving quinine, n=14 receiving quinidine)
Comparison
Quinidine vs Quinine
Design
Cohort
Authors
Discussion
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Implication
Quinidine was associated with greater QT prolongation per concentration than quinine in malaria; leaves open arrhythmia risk and treatment implications.
Structured PICO
Does quinidine cause greater QT prolongation compared to quinine in patients treated for Plasmodium falciparum malaria?
P
Population
45 patients being treated for Plasmodium falciparum malaria (n=31 receiving quinine, n=14 receiving quinidine)
I
Intervention
Quinidine
C
Comparator
Quinine
O
Outcome
Electrocardiographic changes (QT prolongation, T-wave flattening) and cardiotoxicitysurrogate
Quinidine causes significantly greater QT prolongation than quinine at therapeutic plasma concentrations in patients with malaria, though neither showed overt cardiotoxicity.
Cite This Study
White et al. (1983) studied this question.