Key result
Transcatheter mitral valve replacement shows promising feasibility for severe mitral regurgitation, but further trials are needed before it becomes a definitive therapeutic option.
Why the study?
TMVR offers potential advantages over transcatheter repair for severe MR in high-risk patients, but engineering challenges and needed developments remain before it can be a definitive option.
TMVR offers a promising alternative to transcatheter repair for severe MR in high-risk patients, but significant engineering and clinical challenges remain before widespread adoption.
TMVR feasibility in high-risk MR remains hypothesis-generating; leaves open need for dedicated anchoring systems and randomized durability data.
Transcatheter mitral valve replacement (TMVR) is a novel therapeutic option for patients with severe mitral regurgitation (MR) at high or prohibitive surgical risk. Most TMVR technologies under investigation use either a trans-apical or a trans-septal approach via dedicated multistep anchoring systems. Transcatheter mitral valve replacement offers several potential advantages over transcatheter repair, notably a greater and more sustained MR reduction. At the same time, significant engineering challenges and potential disadvantages must be acknowledged. Preclinical and clinical studies have shown promising results, demonstrating TMVR feasibility. Nevertheless, further development, testing, and trials are needed before considering TMVR as a definitive therapeutic option for MR in a wide range of anatomical scenarios.
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Bartorelli et al. (2022) conducted a review in Severe mitral regurgitation (MR) at high or prohibitive surgical risk. Transcatheter mitral valve replacement (TMVR) vs. Transcatheter repair was evaluated. Transcatheter mitral valve replacement shows promising feasibility for severe mitral regurgitation, but further trials are needed before it becomes a definitive therapeutic option.
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