Key result
First-pass myocardial perfusion defects and delayed contrast enhancement on MRI were associated with significantly reduced regional left ventricular wall thickening (63.1% and 75.2%, respectively, vs 103.5% in normal blocks) in patients with hypertrophic cardiomyopathy.
Why the study?
Does abnormal signal intensity on first-pass myocardial perfusion and delayed contrast-enhanced MRI correlate with left ventricular regional contractile dysfunction in patients with hypertrophic cardiomyopathy?
Cross-Sectional (n=12)
No
Does abnormal signal intensity on first-pass myocardial perfusion and delayed contrast-enhanced MRI correlate with left ventricular regional contractile dysfunction in patients with hypertrophic cardiomyopathy?
Absolute Event Rate: 63.1% vs 103.5%
p-value: p=<0.0001
In patients with hypertrophic cardiomyopathy, abnormal signal intensity on first-pass myocardial perfusion and delayed contrast-enhanced MRI is closely related to impaired left ventricular regional contractile function.
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Supports MRI-perfusion and enhancement defects as markers of regional dysfunction in HCM; leaves open prognostic value and therapeutic implications.
Matsunaka et al. (2003) conducted a cross-sectional in Hypertrophic cardiomyopathy (n=12). First-pass myocardial perfusion and delayed contrast-enhanced MRI vs. Myocardial blocks with normal perfusion and no delayed enhancement was evaluated on Percent wall thickening (p=<0.0001). First-pass myocardial perfusion defects and delayed contrast enhancement on MRI were associated with significantly reduced regional left ventricular wall thickening (63.1% and 75.2%, respectively, vs 103.5% in normal blocks) in patients with hypertrophic cardiomyopathy.
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