Key result
HDLs from elderly subjects demonstrated a significantly lower capacity to promote cholesterol efflux compared with HDLs from young subjects (41.7% vs 49.0%; P=0.013).
Why the study?
Does aging reduce the capacity of HDLs to promote cholesterol efflux in macrophages?
Population
HDLs isolated from plasma of young and elderly subjects, tested on THP-1 and J774 macrophages
Comparison
HDLs from elderly subjects (E-HDL) vs HDLs from young subjects (Y-HDL)
Design
Preclinical
Authors
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May heighten age-related CVD risk; leaves open therapeutic targeting in humans.
Observational
Does aging reduce the capacity of HDLs to promote cholesterol efflux in macrophages?
Absolute Event Rate: 41.7% vs 49%
p-value: p=0.013
Aging reduces the capacity of HDLs to promote cholesterol efflux, primarily through the ABCA1 pathway, which may contribute to the increased incidence of cardiovascular disease in the elderly.
Berrougui et al. (2006) reported an observational. Aging (Elderly subjects) vs. Young subjects was evaluated on HDL-mediated cholesterol efflux capacity (p=0.013). HDLs from elderly subjects demonstrated a significantly lower capacity to promote cholesterol efflux compared with HDLs from young subjects (41.7% vs 49.0%; P=0.013).