Key result
ANGPTL4 deficiency in mice resulted in a significantly thinner epidermis (21.9 vs 32.5 μm) and impaired differentiation, indicating PPAR β/δ regulates epidermal maturation via ANGPTL4.
Population
Human primary keratinocytes, organotypic skin cultures, and pure-bred wild type and ANGPTL4-knockout mice on…
Comparison
PPARβ/δ agonist GW501516, recombinant ANGPTL4… vs Vehicle, scrambled siRNA, or wild-type mice
Design
Preclinical
Authors
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Should not change clinical practice; leaves open ANGPTL4 as a human epidermal target.
Absolute Event Rate: 21.9% vs 32.5%
p-value: p=<0.01
PPARβ/δ regulates epidermal maturation via an ANGPTL4-mediated signaling pathway involving PKC and AP-1 activation.
Pal et al. (2011) studied Epidermal differentiation. ANGPTL4 deficiency (knockout/knockdown) vs. Wildtype / Scrambled control was evaluated on Epidermal thickness (μm) (p=<0.01). ANGPTL4 deficiency in mice resulted in a significantly thinner epidermis (21.9 vs 32.5 μm) and impaired differentiation, indicating PPAR β/δ regulates epidermal maturation via ANGPTL4.
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