Oxygen Transport in Vivo by Means of Perfluorochemical Preparations

For many years a search has been under way for oxygen-transporting materials that can be used in blood replacement. At one time it was natural to consider hemoglobin the only practical solution to this problem. Hemoglobin preparations free of insoluble residues of red cells have been produced, and they have greatly reduced the kidney damage associated with earlier products. Other compounds, such as polyhemoglobin, are being developed to circumvent the rapid loss of hemoglobin from the circulation that occurs when it is given intravenously. Little clinical work has been done with hemoglobin or its derivatives to date, but a number . . .