What question did this study set out to answer?

To determine how human ageing influences the absolute numbers of functional natural killer cell subsets within peripheral blood.

November 29, 2006Immunity & AgeingOpen Access

Ageing is associated with a decline in peripheral blood CD56bright NK cells

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Authors

SCShivani M ChidrawarUniversity of Birmingham NKNaeem KhanWestern Michigan University YCY L Tracey ChanUniversity of Birmingham

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Implication

Observational study reveals a selective decline in peripheral blood CD56bright NK cells with age, suggesting impaired innate immune cytokine regulation in older adults.

Key Points

To determine how human ageing influences the absolute numbers of functional natural killer cell subsets within peripheral blood.
Quantified peripheral blood CD56+CD3- natural killer (NK) cells and compared functional subsets (CD56bright and CD56dim) across different age groups, including individuals aged 20–40 years and 60+ years.
Total circulating NK cell counts and CD56dim cytotoxic subset numbers remained stable with advancing age.
Absolute numbers of cytokine-producing CD56bright NK cells declined significantly by 48%, dropping from a mean of 15.6/µL in individuals aged 20–40 years to 8.1/µL in individuals aged 60+ years (p = 0.0004).

Cite This Study

Chidrawar et al. (2006) studied this question.

synapsesocial.com/papers/6a78a7c14fe2e6ffd8ed8fbb https://doi.org/10.1186/1742-4933-3-10

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Implication

Observational study reveals a selective decline in peripheral blood CD56bright NK cells with age, suggesting impaired innate immune cytokine regulation in older adults.

Ageing is associated with a decline in peripheral blood CD56bright NK cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Ageing is associated with a decline in peripheral blood CD56bright NK cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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