Why the study?
Does angiotensin II receptor blockade with CS-866 prevent cardiac hypertrophy and alter PKC/ERK1/2 signaling in a rat model of progressive renal injury?
Does angiotensin II receptor blockade with CS-866 prevent cardiac hypertrophy and alter PKC/ERK1/2 signaling in a rat model of progressive renal injury?
Angiotensin II receptor blockade prevents cardiac hypertrophy in a rat model of progressive renal injury by inhibiting PKC and ERK1/2 activation.
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Suggests BP-independent ARB effects in experimental renal failure; hypothesis-generating for human cardiorenal applications.
Takahashi et al. (2004) studied this question.
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