Key result
Hypertensive disorders of pregnancy were associated with significantly higher P-wave (41.74 vs 37.73, p<0.001) and QTc dispersion (45.44 vs 39.77, p<0.001) compared to healthy pregnant controls.
Why the study?
Do hypertensive disorders of pregnancy increase P-wave and QT dispersion compared to healthy pregnancies?
Observational (n=250)
Do hypertensive disorders of pregnancy increase P-wave and QT dispersion compared to healthy pregnancies?
Hypertensive disorders of pregnancy, particularly preeclampsia and chronic hypertension, are associated with increased P-wave and QTc dispersion, highlighting a potential marker for future cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Elevated P-wave and QT dispersion in hypertensive pregnancy are hypothesis-generating; prospective studies needed before clinical adoption.
Aim: To compare P-wave and QT dispersion values in hypertensive disorders of pregnancy and controls and also in preeclampsia, chronic hypertension, and gestational hypertension separately.Material and methods: We included 140 hypertensive pregnants and 110 healthy age-matched pregnants in this study. The hypertensive pregnants were divided into three subgroups: preeclampsia (n = 43), chronic hypertension (n = 51), and gestational hypertension (n = 46). P-wave and QT dispersion values were compared between groups.Results: Hypertensive pregnants had higher P-wave (41.74 ± 5.51 vs. 37.73 ± 5.62, p < .001) and QTc dispersion (45.44 ± 7.62 vs. 39.77 ± 8.34, p < .001) values. In subgroup analysis, P-wave dispersion and QTc dispersion were different between preeclamptic, chronic hypertensive, and gestational hypertensive patients. Also, they were significantly higher in chronic hypertension as compared to gestational hypertension and they were higher in preeclampsia than in gestational hypertension. No difference was found according to these parameters between preeclampsia and chronic hypertension. In correlation analysis, both P-wave dispersion and QTc dispersion were positively correlated with systolic (r = 0.409, p < .001 and r = 0.306, p < .001) and diastolic blood pressure (r = 0.390, p < .001 and r = 0.287, p < .001) which are main clinical determinants of hypertensive disorders.Conclusion: In clinical practice, chronic hypertensive pregnants are generally followed up in their future life for cardiovascular disorders. Also, we recommend that we must inform and follow preeclamptic patients for future cardiovascular diseases.
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Çakmak et al. (2018) conducted an observational in Hypertensive disorders of pregnancy (n=250). Hypertensive disorders of pregnancy vs. Healthy age-matched pregnancies was evaluated on P-wave dispersion (p=< .001). Hypertensive disorders of pregnancy were associated with significantly higher P-wave (41.74 vs 37.73, p<0.001) and QTc dispersion (45.44 vs 39.77, p<0.001) compared to healthy pregnant controls.
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