Why the study?
Hypertensive disorders of pregnancy are the most common complication of pregnancy and a major cause of maternal and perinatal morbidity and mortality, prompting comparison of hemodynamics between healthy pregnant women and those with gestational hypertension or preeclampsia.
Do gestational hypertension and preeclampsia alter cardiac hemodynamics compared to normal pregnancy, and does methyldopa treatment improve these parameters?
Population
120 pregnant women aged 17 to 42 years
Comparison
Normotensive pregnant women vs pregnant women with GH or PE (treated with methyldopa vs untreated)
Design
Comparative cross-sectional study
Key result
Untreated pregnant women with gestational hypertension or preeclampsia had significantly higher mean arterial pressure compared to healthy pregnant women (113.66 vs 82.81 mm Hg, p<0.001).
Authors
Loading...
May identify subclinical hemodynamic changes in HDP; leaves open whether routine echocardiography improves outcomes.
Cross-Sectional (n=120)
Do gestational hypertension and preeclampsia alter cardiac hemodynamics compared to normal pregnancy, and does methyldopa treatment improve these parameters?
Absolute Event Rate: 113.66% vs 82.81%
p-value: p=<0.001
Pregnant women with gestational hypertension or preeclampsia exhibit significant adverse hemodynamic changes that are partially reversed by methyldopa treatment, supporting the utility of routine echocardiographic assessment in this population.
SHIRIC IRANI K. JEYAPALAN J. MCHUGO J. A. (2018) conducted a cross-sectional in Gestational hypertension or preeclampsia (n=120). Gestational hypertension or preeclampsia vs. Normotensive pregnant women was evaluated on Mean arterial pressure (MAP) (p=<0.001). Untreated pregnant women with gestational hypertension or preeclampsia had significantly higher mean arterial pressure compared to healthy pregnant women (113.66 vs 82.81 mm Hg, p<0.001).