Why the study?
Hypertensive disorders of pregnancy can cause subclinical cardiac dysfunction, but traditional echocardiographic parameters often fail to detect early myocardial and atrial abnormalities.
Do pregnant women with hypertensive disorders exhibit impaired left atrial strain and compliance compared to normotensive pregnancies?
Population
73 pregnant women from 20 weeks of gestation onward (38 with HDP, 35 normotensive)
Comparison
Hypertensive disorders of pregnancy vs normotensive pregnancies
Design
Prospective observational study
Key result
Hypertensive disorders of pregnancy were associated with significantly reduced left atrial compliance compared to normotensive pregnancies, serving as an independent predictor of the condition (OR 0.50).
Authors
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LA strain/compliance detect subclinical dysfunction in HDP despite preserved EF; leaves open their utility for routine risk stratification.
Case-Control (n=73)
Single-blind
No
Do pregnant women with hypertensive disorders exhibit impaired left atrial strain and compliance compared to normotensive pregnancies?
Odds Ratio: 0.5 (95% CI 0.33–0.76)
Absolute Event Rate: 3.87% vs 5.57%
p-value: p=0.001
Advanced echocardiographic parameters, specifically left atrial strain and compliance, can detect early subclinical cardiac dysfunction in pregnant women with hypertensive disorders despite preserved ejection fraction.
Maselienė et al. (2025) conducted a case-control in Hypertensive disorders of pregnancy (n=73). Hypertensive disorders of pregnancy vs. Normotensive pregnancies was evaluated on Left atrial compliance (LASr/E/e′) (OR 0.50, 95% CI 0.33-0.76, p=0.001). Hypertensive disorders of pregnancy were associated with significantly reduced left atrial compliance compared to normotensive pregnancies, serving as an independent predictor of the condition (OR 0.50).