What does this research mean for the field?

Gestational hypertension and preeclampsia are associated with significant maternal cardiac remodeling, including ventricular dilatation, impaired diastolic function, and marked left atrial enlargement despite preserved ejection fraction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 14, 2025CureusOpen Access

Gestational hypertension and preeclampsia linked to cardiac remodeling, notably ~80% higher LAVI versus controls.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Gestational hypertension and preeclampsia (n=80). Intervention: Gestational hypertension and preeclampsia vs. Normotensive pregnant women. Primary outcome: Left atrial volume index (LAVI) (Cohen's d 5.47, 95% CI 4.78-7.00, p=<0.001).

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Why the study?

Hypertensive disorders of pregnancy induce cardiac structural and functional adaptations with potential long-term cardiovascular risks, but detailed echocardiographic characterization compared to normotensive controls was needed.

Do pregnant women with gestational hypertension or preeclampsia exhibit echocardiographic structural and functional cardiac alterations compared to normotensive pregnant women?

Population

80 pregnant women aged 18-34 years in the third trimester

Comparison

Gestational hypertension or preeclampsia vs normotensive controls

Design

Comparative cross-sectional study

Key result

Gestational hypertension and preeclampsia were associated with significant cardiac remodeling, notably a pronounced increase in left atrial volume index (31.52 vs 17.56 mL/m²) compared to controls.

Discussion

Member takes

Overview

Gestational hypertension linked to subclinical remodeling; hypothesis-generating and should not yet change practice pending longitudinal data.

Study Design

Type

Cross-Sectional (n=80)

Multicenter

Structured PICO

Do pregnant women with gestational hypertension or preeclampsia exhibit echocardiographic structural and functional cardiac alterations compared to normotensive pregnant women?

Population

80 pregnant women aged 18-34 years in their third trimester, including 40 with gestational hypertension or preeclampsia and 40 normotensive controls, underwent cross-sectional echocardiographic assessment.

Exposure

Gestational hypertension and preeclampsia

Comparator

Normotensive pregnant controls matched for age and parity

Outcome

Echocardiographic differences including left ventricular morphology, systolic function, diastolic performance, left atrial volumetric measurements, and pulmonary hemodynamicssurrogate

Main Result

Standardized Mean Difference: 5.47 (95% CI 4.78–7)

Absolute Event Rate: 31.52% vs 17.56%

p-value: p=<0.001

Gestational hypertension and preeclampsia are associated with significant subclinical cardiac structural and functional alterations, including ventricular remodeling, diastolic dysfunction, and left atrial enlargement.

Limitations

Single-center design limits generalizability to diverse populations
Cross-sectional methodology precludes longitudinal assessment of cardiac function evolution
Convenience sampling approach may introduce selection bias
No formal assessment of intra- and interobserver variability for echocardiographic measurements
Absence of advanced echocardiographic techniques such as speckle-tracking strain analysis
Lack of long-term follow-up data to evaluate prognostic significance
Potential confounding factors (medications, comorbidities, lifestyle) were not comprehensively controlled

Cite This Study

A 2025 study conducted a cross-sectional in Gestational hypertension and preeclampsia (n=80). Gestational hypertension and preeclampsia vs. Normotensive pregnant women was evaluated on Left atrial volume index (LAVI) (Cohen's d 5.47, 95% CI 4.78-7.00, p=<0.001). Gestational hypertension and preeclampsia were associated with significant cardiac remodeling, notably a pronounced increase in left atrial volume index (31.52 vs 17.56 mL/m²) compared to controls.

synapsesocial.com/papers/6aa60effd3d41ccc68922a5e https://doi.org/10.7759/cureus.92324

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September 14, 2025CureusOpen Access

Gestational hypertension and preeclampsia linked to cardiac remodeling, notably ~80% higher LAVI versus controls.

View Full Paper

Ask AI

Bookmark

Why the study?

Do pregnant women with gestational hypertension or preeclampsia exhibit echocardiographic structural and functional cardiac alterations compared to normotensive pregnant women?

Population

80 pregnant women aged 18-34 years in the third trimester

Comparison

Gestational hypertension or preeclampsia vs normotensive controls

Design

Comparative cross-sectional study

Key result

Gestational hypertension and preeclampsia were associated with significant cardiac remodeling, notably a pronounced increase in left atrial volume index (31.52 vs 17.56 mL/m²) compared to controls.

Discussion

Member takes

Overview

Gestational hypertension linked to subclinical remodeling; hypothesis-generating and should not yet change practice pending longitudinal data.

Study Design

Type

Cross-Sectional (n=80)

Multicenter

Structured PICO

Do pregnant women with gestational hypertension or preeclampsia exhibit echocardiographic structural and functional cardiac alterations compared to normotensive pregnant women?

Population

Exposure

Gestational hypertension and preeclampsia

Comparator

Normotensive pregnant controls matched for age and parity

Outcome

Echocardiographic differences including left ventricular morphology, systolic function, diastolic performance, left atrial volumetric measurements, and pulmonary hemodynamicssurrogate

Main Result

Standardized Mean Difference: 5.47 (95% CI 4.78–7)

Absolute Event Rate: 31.52% vs 17.56%

p-value: p=<0.001

Limitations

Single-center design limits generalizability to diverse populations
Cross-sectional methodology precludes longitudinal assessment of cardiac function evolution
Convenience sampling approach may introduce selection bias
No formal assessment of intra- and interobserver variability for echocardiographic measurements
Absence of advanced echocardiographic techniques such as speckle-tracking strain analysis
Lack of long-term follow-up data to evaluate prognostic significance
Potential confounding factors (medications, comorbidities, lifestyle) were not comprehensively controlled

Cite This Study

synapsesocial.com/papers/6aa60effd3d41ccc68922a5e https://doi.org/10.7759/cureus.92324

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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