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June 3, 2026Journal of Hypertension

Relationship Between Changes in Cardiac Structure and Function in Pregnant Women With Gestational Hypertension and the Development of Preeclampsia

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Key result

Greater second-to-third trimester drop in LV systolic velocity linked to ~12% higher preeclampsia risk.

  • OR 1.12
  • P=0.04
  • n=218

Why the study?

To investigate the relationship between changes in cardiac structure and function in patients with gestational hypertension and the development of preeclampsia.

Population

Pregnant women with gestational hypertension (n=135) and preeclampsia (n=83)

Comparison

Gestational hypertension vs preeclampsia

Design

Retrospective study

Authors

ZLZhaoping LiPeking UniversityJGJ GaoMcGovern Institute for Brain ResearchSCShaomin ChenNorth China Electric Power University

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Implication

Greater Sm decline was associated with preeclampsia; leaves open whether serial echocardiography aids risk stratification in gestational hypertension.

Key Points

  • This study explores how changes in cardiac structure and function relate to the risk of developing preeclampsia in pregnant women with gestational hypertension.
  • Retrospective study involving pregnant women with gestational hypertension (n=135) and preeclampsia (n=83).
  • Echocardiographic examinations were conducted in the second and third trimesters.
  • Binary logistic regression assessed the association between cardiac changes and preeclampsia occurrence.
  • Preeclampsia group had earlier delivery gestational age and higher rates of twin pregnancies (P<0.05).
  • Left ventricular systolic velocity (Sm) was lower in the preeclampsia group (11.01 vs 11.79 cm/s, P=0.019).
  • Sm decline was greater in preeclampsia (2.47 vs 1.20 cm/s, P<0.001) and associated with preeclampsia occurrence (OR=1.12, P=0.04).

Study Design

Type

Observational (n=218)

Structured PICO

P
Population
218 pregnant women with gestational hypertension (n=135) and preeclampsia (n=83) who underwent echocardiography in the second and third trimesters.
O
Outcome
Occurrence of preeclampsia

Main Result

Odds Ratio: 1.12

p-value: p=0.04

A greater decline in left ventricular systolic and diastolic function from the second to third trimester is independently associated with the development of preeclampsia in women with gestational hypertension.

Cite This Study

Li et al. (2026) conducted an observational in Gestational hypertension and preeclampsia (n=218). Decrease in left ventricular lateral wall mitral annular systolic velocity (Sm) vs. Gestational hypertension without preeclampsia was evaluated on Preeclampsia occurrence (OR 1.12, p=0.04). A greater decrease in left ventricular systolic velocity (Sm) from the second to third trimester was independently associated with the development of preeclampsia (OR 1.12, P=0.04).

synapsesocial.com/papers/6a1fc530dee9eb8c0dce6913https://doi.org/10.1097/01.hjh.0001197160.28709.06
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Echocardiographic Assessment of Structural and Functional Cardiac Alterations in Gestational Hypertension and Preeclampsia: A Comparative Cross-Sectional Study2025
  2. 2Echocardiographic Heart Changes in Pregnancies Complicated with Gestation Hypertension and Preeclampsia2019
  3. 3Maternal Cardiac Functional and Structural Changes in Preeclampsia: an Echocardiographic Study2023
  4. 4Pregnancy related cardiac remodeling in patients with and without hypertension -preliminary results2026
  5. 5Left ventricular dysfunction in preeclamptic patients2018