Key result
Normotensive pregnancy was associated with increased cardiac output (MD 1.41 l/min; 95% CI 1.18-1.63) and decreased vascular resistance (MD -331 dyn·sec-1·cm-5; 95% CI -384 to -277) in the third trimester.
Why the study?
In-depth insight into haemodynamic changes during normotensive pregnancy was needed to help identify women at risk for gestational hypertensive complications.
How do cardiac output and peripheral vascular resistance change during normotensive and hypertensive pregnancies compared to non-pregnant reference values?
Meta-Analysis
How do cardiac output and peripheral vascular resistance change during normotensive and hypertensive pregnancies compared to non-pregnant reference values?
Mean Difference: 1.41 (95% CI 1.18–1.63)
Hemodynamic changes, specifically cardiac output and vascular resistance, differ significantly between normotensive and hypertensive pregnancies, suggesting serial monitoring could identify women at risk for hypertensive complications.
No takes yet. Share an insight, caveat, or question.
May support serial hemodynamic monitoring to flag hypertensive risk; extends evidence with normative trajectories for trials and practice.
Mulder et al. (2021) conducted a meta-analysis in Normotensive and hypertensive pregnancy. Normotensive pregnancy vs. Non-pregnant reference measurement was evaluated on Cardiac output in early third trimester (MD 1.41, 95% CI 1.18-1.63). Normotensive pregnancy was associated with increased cardiac output (MD 1.41 l/min; 95% CI 1.18-1.63) and decreased vascular resistance (MD -331 dyn·sec-1·cm-5; 95% CI -384 to -277) in the third trimester.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: