Key result
Hypertensive pregnancy showed exaggerated left ventricular mass and elevated total peripheral resistance, which was normalized by oxprenolol treatment without reducing cardiac output.
Why the study?
How do echocardiographic haemodynamic and left ventricular parameters differ between normotensive and hypertensive pregnancies, and how are they affected by antihypertensive treatments like oxprenolol?
Observational (n=57)
How do echocardiographic haemodynamic and left ventricular parameters differ between normotensive and hypertensive pregnancies, and how are they affected by antihypertensive treatments like oxprenolol?
Oxprenolol normalizes total peripheral resistance in hypertensive pregnancy without compromising cardiac output or heart rate, which may contribute to improved fetal outcomes.
Answers are grounded in this paper and cite their sources.
Oxprenolol may normalize resistance without output compromise in hypertensive pregnancy; leaves open fetal outcome benefits pending randomized confirmation.
Echocardiographic haemodynamic and left ventricular parameters were determined in twenty-one normontensives and thirty-six hypertensives during the last trimester of pregnancy. 2. Equivalent blood pressure control was obtained in hypertensives with bet rest only, oxprenolol or methyldopa, but remained above normotensive levels. 3. Cardiac output was elevated in the last trimester of pregnancy in normotensivves and hypertensives. 4. Left ventricular mass was increased in normal pregnancy, but displayed an exaggerated increase in hypertensives. 5. Total peripheral resistance was inappropriately elevated in hypertensive pregnancy, but was normalized in the oxprenolol-treated group. 6. There was no reduction in heart rate or cardiac output in the beta-adrenoreceptor blocker-treated group. This feature, in combination with lowered peripheral resistance, may contribute to the improvement in foetal outcome observed in maternal hypertension of pregnancy treated with oxprenolol.
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Larkin et al. (1980) conducted an observational in Hypertension in pregnancy (n=57). Hypertension and antihypertensive treatments (oxprenolol, methyldopa) vs. Normotensive pregnancy and bed rest only was evaluated on Echocardiographic haemodynamic and left ventricular parameters. Hypertensive pregnancy showed exaggerated left ventricular mass and elevated total peripheral resistance, which was normalized by oxprenolol treatment without reducing cardiac output.
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