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January 1, 2016Journal of Cardiovascular UltrasoundOpen Access

Hypertensive pregnancy is linked to ~15% higher LVMI and impaired diastolic function versus normotensive pregnancy.

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Why the study?

Does hypertension during pregnancy alter left ventricular structure and diastolic function compared to normotensive pregnancy?

Population

193 consecutive pregnant women, including normotensive and hypertensive women

Comparison

Hypertension during pregnancy vs Normotensive pregnancy

Design

Cross-sectional

Key result

Hypertensive pregnancy was associated with significantly higher left ventricular mass index (97 vs 84 g/m, p=0.001) and impaired diastolic function compared to normotensive pregnancy.

Authors

MKMi Jeong KimJSJonggoo SeoKCKyoung Im Cho

Discussion

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Overview

May indicate modified LV remodeling in hypertensive pregnancies; leaves open prognostic implications and need for prospective validation.

Study Design

Type

Observational (n=193)

Multicenter

No

Structured PICO

Does hypertension during pregnancy alter left ventricular structure and diastolic function compared to normotensive pregnancy?

P
Population
193 pregnant women, including 130 with hypertension and 63 normotensive controls, underwent retrospective echocardiographic assessment.
E
Exposure
Hypertension during pregnancy (gestational hypertension or chronic hypertension)
C
Comparator
Normotensive pregnancy
O
Outcome
Left ventricular mass indexed by height and diastolic function (E/e' ratio)surrogate

Main Result

Absolute Event Rate: 97% vs 84%

p-value: p=0.001

Hypertensive pregnancy is associated with significant left ventricular hypertrophy and diastolic dysfunction, with different remodeling patterns observed between gestational and chronic hypertension.

Limitations

  • Retrospective design
  • Single measurement at different gestational ages
  • Small proportion of patients with severe preeclampsia
  • Lack of data regarding peripheral resistance and pregnancy outcome
  • Small sample size

Cite This Study

Kim et al. (2016) conducted an observational in Hypertension-Related Pregnancy (n=193). Hypertension during pregnancy vs. Normotensive pregnancy was evaluated on Left ventricular mass index (LVMI) normalized by height (p=0.001). Hypertensive pregnancy was associated with significantly higher left ventricular mass index (97 vs 84 g/m, p=0.001) and impaired diastolic function compared to normotensive pregnancy.

synapsesocial.com/papers/6aa2ee89e7c447fa74a8a35ehttps://doi.org/10.4250/jcu.2016.24.1.28
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pregnancy related cardiac remodeling in patients with and without hypertension -preliminary results2026
  2. 2Left Ventricular Function in Gestational Hypertension: Serial Echocardiographic Study2009 · 26 citations
  3. 3Disproportionate Pregnancy-Induced Myocardial Hypertrophy in Women With Essential Hypertension2013 · 10 citations
  4. 4Echocardiographic Assessment of Structural and Functional Cardiac Alterations in Gestational Hypertension and Preeclampsia: A Comparative Cross-Sectional Study2025
  5. 5Echocardiographic Assessment of Cardiovascular Hemodynamic Changes in Hypertensive Disorders of Pregnancy2026