Key result
Hypertensive pregnancy is linked to ~15% higher LVMI and impaired diastolic function versus normotensive pregnancy.
Why the study?
Does hypertension during pregnancy alter left ventricular structure and diastolic function compared to normotensive pregnancy?
Observational (n=193)
No
Does hypertension during pregnancy alter left ventricular structure and diastolic function compared to normotensive pregnancy?
Answers are grounded in this paper and cite their sources.
Hypertensive pregnancy is associated with significant left ventricular hypertrophy and diastolic dysfunction, with different remodeling patterns observed between gestational and chronic hypertension.
BACKGROUND: Pregnancy induces dramatic cardiovascular changes in order to meet the increasing metabolic needs. Adaptive change of left ventricle (LV) might be modified in pregnancy complicated by hypertension. METHODS: Data from 193 consecutive pregnant women were analyzed. Clinical and echocardiographic data were compared in normotensive and hypertensive women. RESULTS: Significantly higher LV mass indexed by height was observed in hypertensive women compared with normotensive women (84 ± 21 g/m vs. 97 ± 20 g/m, p = 0.001). Diastolic function measured by the ratio of peak velocity of early diastolic transmitral blood flow to early diastolic mitral annular velocity was impaired in hypertensive women (11.0 ± 3.0 vs. 9.2 ± 2.5, p < 0.001). Such change was more prominent in women with gestational hypertension (GH) than those with chronic hypertension (CH). Heavy maternal weight was an independent factor associated with LV hypertrophy (LVH) in both normotensive and hypertensive women. Overt eccentric LVH was more frequent than concentric remodeling/hypertrophy (24% vs. 8.4%) in GH, while the opposite result was observed in CH (14% vs. 23%). CONCLUSION: Hypertensive pregnancy is associated with significant LVH and diastolic dysfunction. CH seems to induce different LV remodeling pattern from GH. Heavy maternal weight during pregnancy might intensify the unfavorable remodeling of LV, particularly in hypertensive pregnancy.
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Kim et al. (2016) conducted an observational in Hypertension-Related Pregnancy (n=193). Hypertension during pregnancy vs. Normotensive pregnancy was evaluated on Left ventricular mass index (LVMI) normalized by height (p=0.001). Hypertensive pregnancy was associated with higher left ventricular mass index and impaired diastolic function compared to normotensive pregnancy.
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