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March 8, 2013American Journal of HypertensionOpen Access

Myocardial hypertrophy was independently associated with hypertension (OR = 11.1, 95% CI = 3.2-38.5; P < 0.001) and pregnancy (OR = 6.1, 95% CI = 2.6-14.3; P < 0.001), with the risk additionally increased in hypertensive women during pregnancy (OR = 4.3, 95% CI = 1.7-10.9; P = 0.002).

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Why the study?

Does the combination of pregnancy and arterial hypertension synergistically increase the risk of myocardial hypertrophy and diastolic dysfunction in women?

Population

193 women divided into 4 groups: hypertensive pregnant, normotensive pregnant, hypertensive nonpregnant, and…

Comparison

Pregnancy in the setting of arterial hypertension vs Normotensive pregnant, hypertensive nonpregnant…

Design

Cross-sectional

Authors

SBSilméia Garcia Zanati BazanVBVera Therezinha Medeiros BorgesLMLuis Cuadrado Martín

Discussion

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Overview

May warrant echocardiographic assessment in hypertensive pregnancies; cross-sectional data leaves open causal and prognostic implications.

Structured PICO

Does the combination of pregnancy and arterial hypertension synergistically increase the risk of myocardial hypertrophy and diastolic dysfunction in women?

P
Population
193 women divided into 4 groups: hypertensive pregnant (HTP; n = 57), normotensive pregnant (NTP; n = 47), hypertensive nonpregnant (HTNP; n = 41), and normotensive nonpregnant (NTNP; n = 48)
I
Intervention
Pregnancy in the setting of arterial hypertension
C
Comparator
Normotensive pregnant, hypertensive nonpregnant, and normotensive nonpregnant states
O
Outcome
Myocardial hypertrophy (LVH) and left ventricular function (diastolic dysfunction)surrogate

Hypertension and pregnancy have a synergistic prohypertrophic effect on the heart, significantly increasing the risk of myocardial hypertrophy and diastolic dysfunction in women.

Cite This Study

Bazan et al. (2013) studied this question.

synapsesocial.com/papers/6a7d08c8a7839e36ac1cc4e6https://doi.org/10.1093/ajh/hpt023
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Echocardiographic Assessment of Structural and Hemodynamic Changes in Hypertension-Related Pregnancy2016 · 31 citations
  2. 2Evolution of Myocardial Hypertrophy Associated With Pregnancy in Hypertensive Women Six Months Postpartum2023 · 3 citations
  3. 3Impact of Gestational Hypertension on Left Ventricular Function and Geometric Pattern2011 · 35 citations
  4. 4Echocardiographic Assessment of LV Geometric Pattern and Function in Pregnancy-Induced Hypertension2005 · 5 citations
  5. 5Left Ventricular Hypertrophy in Women With a History of Preeclampsia2024 · 9 citations