Key result
The abstract outlines an investigation into the interplay between TG-related indices, CT findings, and patient outcomes in a general population cohort, but reports no quantitative results.
Why the study?
To investigate the interplay between TG-related indices, non-contrast CT findings including epicardial fat volume and coronary artery calcium score, and patient outcome in the general population.
Do the triglyceride/HDL cholesterol ratio and TyG index predict coronary atherosclerosis and patient outcomes in the general population?
Cohort
Do the triglyceride/HDL cholesterol ratio and TyG index predict coronary atherosclerosis and patient outcomes in the general population?
TG-related indices are being investigated for their interplay with epicardial fat volume, coronary artery calcium, and patient outcomes in the general population.
TyG index may aid CAD risk stratification; extends prior observations but leaves open incremental value in prospective studies.
The combination of increased plasma triglycerides (TGs) and low high-density lipoprotein cholesterol (HDL-C) is an emerging marker of ‘atherogenic dyslipidaemia’ and risk of cardiovascular events in the general population.1 The TG-glucose (TyG) index is calculated as Ln(TG*FPG/2).2 It predicted cardiac events in the general population,3 and the progression of coronary atherosclerosis in patients with known coronary artery disease,4 irrespective of other risk factors, or cholesterol levels. In a cohort from the general population, we investigated specifically the interplay between TG-related indices, findings from non-contrast computed tomography (CT) and patient outcome. From CT scans, epicardial fat volume (EFV) and coronary artery calcium (CAC) score were derived. Epicardial fat is a biologically active organ that surrounds the coronary arteries and promote the development of coronary atherosclerosis.5 EFV then becomes a surrogate indicator of the lipid-rich coronary plaque burden, and then of high-risk atherosclerotic plaques, while the CAC score expresses more stable and calcific coronary atherosclerosis. EFV may have also a prognostic value for future adverse events also beyond CAC scoring.6
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Aimo et al. (2021) conducted a cohort in Coronary atherosclerosis. TG-related indices (TG/HDL-C ratio and TyG index) was evaluated on Patient outcome and findings from non-contrast CT (epicardial fat volume and coronary artery calcium score). The abstract outlines an investigation into the interplay between TG-related indices, CT findings, and patient outcomes in a general population cohort, but reports no quantitative results.
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