August 21, 2006Journal of Neurochemistry

Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain

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Population

Wild-type mice and mice deficient in the inducible form of nitric oxide (iNOSKO)

Design

Preclinical

Authors

JTJitbanjong TangpongWalailak University MCMarsha P. ColeUniversity of Louisville RSRukhsana SultanaJagannath University

Discussion

Member takes

Implication

iNOS may mediate adriamycin-induced brain mitochondrial injury in mice; leaves open relevance to human chemobrain prevention.

Structured PICO

Population

Wild-type mice and mice deficient in the inducible form of nitric oxide (iNOSKO)

Intervention

Adriamycin (ADR) treatment

Outcome

Circulating tumor necrosis factor-alpha levels, mitochondrial respiration, and mitochondrial protein nitration (including MnSOD activity)surrogate

Adriamycin-induced CNS injury (chemobrain) is mediated by nitric oxide, which couples systemic cytokine production with mitochondrial dysfunction and protein nitration in the brain.

Cite This Study

Tangpong et al. (2006) studied this question.

synapsesocial.com/papers/6a78ba94232067cbf2ec4725 https://doi.org/10.1111/j.1471-4159.2006.04179.x

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Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider