Key result
Intraoperative multimodal analgesia with dexmedetomidine, ketamine, and magnesium sulfate significantly reduced median VAS pain scores at 30 minutes post-extubation to 2, compared to 4 and 5 in the high and low-dose opioid groups, respectively.
Why the study?
Inadequate pain control after cardiac surgery complicates recovery, and multimodal analgesia may achieve better analgesia and improve outcomes compared with standard opioid usage.
Does intraoperative multimodal non-opioid analgesia (dexmedetomidine, ketamine, magnesium sulfate) improve postoperative pain and recovery in adults undergoing open heart surgery compared to opioid-based regimens?
Population
90 patients undergoing cardiac surgery with median sternotomy
Comparison
Continuous high-dose opioids vs low-dose opioid boluses vs multimodal non-opioid analgesics
Design
Randomized controlled trial
Authors
Loading...
May support multimodal analgesia after cardiac surgery; leaves open need for confirmatory RCTs before practice change.
RCT (n=90)
Computer-generated randomization sequence
No
Does intraoperative multimodal non-opioid analgesia (dexmedetomidine, ketamine, magnesium sulfate) improve postoperative pain and recovery in adults undergoing open heart surgery compared to opioid-based regimens?
Absolute Event Rate: 2% vs 4%
p-value: p=<0.001
An intraoperative multimodal non-opioid analgesic regimen combining dexmedetomidine, ketamine, and magnesium sulfate improves early postoperative pain control and accelerates recovery after open heart surgery compared to traditional opioid-based regimens.
Morsy et al. (2022) conducted an RCT in Cardiac surgery (n=90). Multimodal non-opioid analgesia (dexmedetomidine, ketamine, magnesium sulfate) vs. High-dose and low-dose opioid regimens was evaluated on Pain at rest assessed at 30 minutes after tracheal extubation using a 100-mm visual analogue scale (VAS) (p=<0.001). Intraoperative multimodal analgesia with dexmedetomidine, ketamine, and magnesium sulfate significantly reduced median VAS pain scores at 30 minutes post-extubation to 2, compared to 4 and 5 in the high and low-dose opioid groups, respectively.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: