The effects of qinghaosu (QHS), dihydroqinghaosu (DHQ), artemether and alpha-propoxycarbonyl dihydroartemisine (SM242) on incorporation of [G-3H] hypoxanthine into Plasmodium falciparum were studied in vitro. Antimalarial activity in vitro is enhanced by reduction of the keto group, since DHQ, artemether and SM242 were more than 100 times more active than QHS.
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Li et al. (1983) studied this question.
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