Population
Rat tissues (platelets, lung, cerebellum, kidney, pancreas) and transfected COS-7 cells
Design
Preclinical
Authors
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Rat PDE5 localization should not guide clinical decisions; leaves open cGMP pathway roles in cerebellum, kidney, and pancreas.
The study demonstrates cell-specific localization of PDE5 in various rat tissues, suggesting the presence of a cGMP/PDE5 pathway in these tissues.
Kotera et al. (2000) studied this question.
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