Key result
The REGAIN trial is a protocol for a randomized controlled trial designed to compare spinal versus general anesthesia on death or inability to walk at 60 days after hip fracture surgery.
Why the study?
Does spinal anaesthesia compared to general anaesthesia improve survival and independence in previously ambulatory patients aged 50 and older undergoing hip fracture surgery?
Population
1600 previously ambulatory patients aged 50 and older undergoing hip fracture surgery
Comparison
Spinal anaesthesia vs General anaesthesia
Design
RCT, randomly allocated, outcome assessors blinded to treatment assignment
Follow-up
60 days (primary), up to 365 days (secondary)
Authors
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This trial protocol outlines a large, pragmatic RCT to determine whether spinal or general anesthesia yields better outcomes for independence and survival after hip fracture surgery.
RCT (n=1,600)
Single-blind
Randomly allocated
Yes
Does spinal anaesthesia compared to general anaesthesia improve survival and independence in previously ambulatory patients aged 50 and older undergoing hip fracture surgery?
This trial protocol outlines a large, pragmatic RCT to determine whether spinal or general anesthesia yields better outcomes for independence and survival after hip fracture surgery.
Neuman et al. (2016) conducted an RCT in Hip fracture (n=1,600). Spinal anesthesia vs. General anesthesia was evaluated on Composite of death or new inability to walk 10 feet or across a room at 60 days after randomisation. The REGAIN trial is a protocol for a randomized controlled trial designed to compare spinal versus general anesthesia on death or inability to walk at 60 days after hip fracture surgery.
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