Key result
Aged mice had a significantly lower maximal heart rate increase in response to sympathetic nerve stimulation compared to young mice (20.5% vs. 73.0%, P<0.05).
Population
Innervated hearts from young (3-4 months, n=10) and aged (20-24 months, n=11) female C57Bl6 mice
Comparison
Sympathetic nerve stimulation at the spinal cord… vs Young (3-4 months) vs. Aged (20-24 months) mice
Design
Preclinical
Authors
Loading...
Diminished SNS responsiveness in aged mouse hearts warrants caution in elderly arrhythmia care; leaves open human translation.
Absolute Event Rate: 20.5% vs 73%
p-value: p=<0.05
Decreased responsiveness to sympathetic nerve stimulation in aged atria is primarily due to decreased β-adrenergic responsiveness, while in aged ventricles it is primarily due to nerve degeneration.
Stuart et al. (2018) studied Ageing (n=21). Ageing vs. Young mice (3-4 months) was evaluated on Maximal heart rate increase with sympathetic nerve stimulation (p=<0.05). Aged mice had a significantly lower maximal heart rate increase in response to sympathetic nerve stimulation compared to young mice (20.5% vs. 73.0%, P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: