Key result
Ageing is associated with changes in cardiovascular responses to pharmacological stimuli, including loss of large artery compliance and increased sympathetic activity, which may be partially reversible.
Population
Ageing patients
Design
Review
Authors
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May warrant age-adjusted dosing in older adults; leaves open reversibility of vascular and autonomic changes.
Understanding age-related changes in cardiovascular physiology and pharmacological responses is crucial, as some of these changes may be partially reversible and have important therapeutic implications.
Moore et al. (2003) conducted a review in Ageing. Ageing was evaluated. Ageing is associated with changes in cardiovascular responses to pharmacological stimuli, including loss of large artery compliance and increased sympathetic activity, which may be partially reversible.
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