Why the study?
Does aging affect norepinephrine spillover and clearance at rest and during submaximal exercise?
Population
15 male subjects (8 young, mean age 26 ± 3 years; 7 old, mean age 69 ± 5 years)
Comparison
20 min of submaximal cycling exercise at 50% of… vs Rest
Design
Cross-sectional
Authors
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Elevated norepinephrine in aging may reflect spillover and clearance changes; hypothesis-generating for sympathetic contributions to cardiovascular risk.
Does aging affect norepinephrine spillover and clearance at rest and during submaximal exercise?
Higher plasma norepinephrine concentrations in older individuals are driven by reduced clearance and increased regional spillover, both at rest and during exercise.
Mazzeo et al. (1997) studied this question.
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