Key result
Healthy septuagenarian men demonstrated a markedly lower maximal cardiac output (11.2 vs. 19.7 L/min) during exercise compared to young men, despite reaching similar peak plasma norepinephrine levels.
Why the study?
Does aging alter the cardiovascular hemodynamic and sympathetic (norepinephrine) response to graded exercise in healthy males?
Cross-Sectional (n=27)
No
Does aging alter the cardiovascular hemodynamic and sympathetic (norepinephrine) response to graded exercise in healthy males?
Absolute Event Rate: 11.2% vs 19.7%
The study demonstrates that reduced cardiac performance during exercise in healthy older men is likely due to decreased cardiac responsiveness to sympathetic stimulation rather than diminished sympathetic activity.
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Suggests age-related decline in exercise cardiac output reflects reduced responsiveness to sympathetic stimulation; hypothesis-generating, should not yet change practice.
Miyazawa et al. (1984) conducted a cross-sectional in Healthy (n=27). Advanced age (Septuagenarians) vs. Young adults (aged 19-37) was evaluated on Maximal cardiac output during exercise (L/min). Healthy septuagenarian men demonstrated a markedly lower maximal cardiac output (11.2 vs. 19.7 L/min) during exercise compared to young men, despite reaching similar peak plasma norepinephrine levels.
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