Key result
Elevated blood pressure in young adults was significantly associated with BMI, hyperuricaemia, and albuminuria in men, and with BMI, hyperuricaemia, and gestational hypertension in women.
Why the study?
Hypertension is highly prevalent in sub-Saharan Africa with an accelerated course to end-stage renal disease, prompting evaluation of whether elevated blood pressure in early adulthood associates with risk factors or renal target-organ damage.
Cohort (n=933)
No
p-value: p=< 0.001
The pathophysiology of elevated blood pressure in young adults differs between genders, highlighting modifiable factors such as BMI and hyperuricaemia in its development.
Early EBP screening may flag renal risk in young South Africans; leaves open whether intervention prevents cardiorenal sequelae.
BACKGROUND: Sub-Saharan Africa has been shown to have a high prevalence of hypertension (58% in rural black South Africans) with an accelerated course ending in end-stage renal disease. We sought to determine whether the prevalence of elevated blood pressure (EBP) in early adulthood was associated with any risk factors and/or renal target-organ damage in young adulthood, which could prevent development of these cardiorenal sequelae. METHODS: = 933; age 28 years; 52% female) participating in the Birth to Twenty Plus (BT20) cohort in Soweto, South Africa. Blood pressure was measured on one occasion. RESULTS: < 0.001). Body mass index (BMI), hyperuricaemia and albuminuria had significant associations with EBP in men. In women, BMI, hyperuricaemia and a self-reported history of gestational hypertension had significant associations. CONCLUSIONS: Our findings suggest that the pathophysiology of EBP in young adults differs between the genders and highlights a number of modifiable factors in its development.
No takes yet. Share an insight, caveat, or question.
Naidoo et al. (2023) conducted a cohort in Elevated blood pressure (n=933). Risk factors (BMI, hyperuricaemia, albuminuria, gestational hypertension) was evaluated on Elevated blood pressure (EBP) (p=< 0.001). Elevated blood pressure in young adults was significantly associated with BMI, hyperuricaemia, and albuminuria in men, and with BMI, hyperuricaemia, and gestational hypertension in women.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: