Key result
The survival benefit of primary prevention implantable cardioverter-defibrillators is attenuated in older adults, and individuals with frailty or multiple comorbidities may not benefit from placement.
Why the study?
Current indications for prophylactic ICD derive from older trials that enrolled few patients aged >75 years, creating a need for data addressing ICD efficacy in older patients and accounting for geriatric syndromes.
Does implantable cardioverter-defibrillator (ICD) placement improve survival in elderly patients with heart failure with reduced ejection fraction and frailty?
Does implantable cardioverter-defibrillator (ICD) placement improve survival in elderly patients with heart failure with reduced ejection fraction and frailty?
The survival benefit of primary prevention ICDs is significantly attenuated in elderly patients with multiple comorbidities and frailty, highlighting the need for individualized risk stratification beyond left ventricular ejection fraction.
The implantable cardioverter-defibrillator (ICD) is the mainstay therapy for primary prevention of sudden cardiac death in patients with heart failure with a reduced ejection fraction. Current indications for prophylactic ICD are based on the results of randomized controlled trials dating back to 15-20 years ago, which have usually enrolled highly selected patients with few comorbidities and only a small number of patients aged >75 years. Existing literature suggest an age-dependent attenuation of the efficacy of the ICD. Because of the ageing of the population, there is need for data addressing device efficacy among older patients that also considers the impact of geriatric syndromes on health status. The assessment of frailty may be of value in identifying elderly patients who may or may not benefit from ICD placement for primary prevention of sudden cardiac death.
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Rovere et al. (2020) conducted a review in Heart failure with reduced ejection fraction. Implantable cardioverter-defibrillator (ICD) vs. No ICD / Medical therapy was evaluated. The survival benefit of primary prevention implantable cardioverter-defibrillators is attenuated in older adults, and individuals with frailty or multiple comorbidities may not benefit from placement.
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