Key result
D-dimer testing for suspected deep venous thrombosis exhibits decreased specificity with advancing age, resulting in a higher rate of false-positive results in elderly patients.
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In patients with suspected deep venous thrombosis (DVT), a very low blood d-dimer concentration, in combination with low clinical probability, can rule out DVT. However, the specificity of d-dimer for DVT decreases with age, leading to more false-positive results in elders. In this retrospective study, investigators evaluated …
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Mueller et al. (2012) studied this question. D-dimer testing for suspected deep venous thrombosis exhibits decreased specificity with advancing age, resulting in a higher rate of false-positive results in elderly patients.
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