Key result
Simplification of the real inlet velocity profile in the right coronary artery significantly affects the computed hemodynamic parameters such as wall shear stress and pressure distribution.
Why the study?
Does the choice of input waveform affect the calculated hemodynamic parameters (WSS, pressure distribution) in patient-specific computational fluid dynamics models of stenosed right coronary arteries?
Does the choice of input waveform affect the calculated hemodynamic parameters (WSS, pressure distribution) in patient-specific computational fluid dynamics models of stenosed right coronary arteries?
In patient-specific computational fluid dynamics models of coronary arteries, using physiologically realistic input waveforms is critical as it drastically alters the calculated wall shear stress and pressure drops compared to mathematical approximations.
Simplified inlet profiles risk inaccurate WSS estimates in coronary CFD; leaves open whether realistic waveforms are required for clinical translation.
Accurate fluid mechanics models are important tools for predicting the flow field in the coronary artery for understanding the relationship between hemodynamics and the initiation and progression of atherosclerosis. The purpose of this paper is to asses non-invasively hemodynamic parameters such as disturbed flows, pressure distribution and wall shear stress with computational fluid dynamics (CFD) in human right coronary artery (RCA) using patient-specific data from in vivo computed tomographic (CT) angiography, using two different pulsatile input waveforms. In order to produce a realistic three-dimensional model of the RCA anatomy, CT-datasets were acquired by a four-row-detector CT-scanner. Digital files in Digital Imaging and Communications in Medicine (DICOM) file format, containing cross-sectional information were then imported to CFD software package for reconstruction. The numerical analysis examines closely the effect of a different input waveforms model on the hemodynamic characteristics such as secondary flow, flow separation and wall shear stress in the multiple stenosed RCA.
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Bernad et al. (2010) studied Right coronary artery atherosclerosis (n=1). Physiologically realistic input waveform (Case 2) vs. Realistic approximation using harmonics (Case 1) was evaluated on Hemodynamic parameters (velocity, pressure drop, wall shear stress). Simplification of the real inlet velocity profile in the right coronary artery significantly affects the computed hemodynamic parameters such as wall shear stress and pressure distribution.
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