What question did this study set out to answer?

To characterize magnetic resonance (MR) imaging abnormalities of the brain in patients with Wilson disease and evaluate their correlation with clinical manifestations.

October 1, 1985Radiology

Wilson disease of the brain: MR imaging.

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Authors

AAAlex M. AisenPhilips (Finland)WMWilliam MartelTufts University TGT O GabrielsenUniversity of Michigan

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Implication

Observational imaging study reveals characteristic symmetric deep gray matter lesions in Wilson disease, highlighting strong correlation with clinical neurological symptoms.

Key Points

To characterize magnetic resonance (MR) imaging abnormalities of the brain in patients with Wilson disease and evaluate their correlation with clinical manifestations.
Obtained brain MR images from 23 patients with biochemically proven Wilson disease.
Performed follow-up MR imaging in five patients at intervals between 4 and 8 months to evaluate interval changes.
Abnormal MR signal findings secondary to Wilson disease were identified in 15 of 23 patients (65%).
Abnormalities were primarily bilaterally symmetric and localized to the lenticular, thalamic, caudate, and dentate nuclei, as well as the brain stem, while a smaller subset exhibited asymmetric focal white-matter lesions.
Imaging abnormalities correlated well with clinical symptoms, and repeat evaluations in five patients demonstrated no significant interval change over 4 to 8 months.

Cite This Study

Aisen et al. (1985) studied this question.

synapsesocial.com/papers/6a78e24bc284d7a4ba5acc1e https://doi.org/10.1148/radiology.157.1.4034959

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Implication

Observational imaging study reveals characteristic symmetric deep gray matter lesions in Wilson disease, highlighting strong correlation with clinical neurological symptoms.

Wilson disease of the brain: MR imaging.

Discussion

Member takes

Implication

Key Points

Cite This Study

Wilson disease of the brain: MR imaging.

Discussion

Member takes

Implication

Key Points

Cite This Study

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