Key result
Left ventricular diastolic dysfunction was not significantly associated with requiring invasive mechanical ventilation at the time of echocardiogram (72% vs 67%; difference +5%; p=0.52).
Why the study?
Left ventricular diastolic dysfunction is linked to difficult ventilator weaning and higher mortality in septic adults, but its association with outcomes in pediatric sepsis was unclear.
Does left ventricular diastolic dysfunction increase the requirement for mechanical ventilation or mortality in children with severe sepsis or septic shock?
Cohort (n=204)
No
Does left ventricular diastolic dysfunction increase the requirement for mechanical ventilation or mortality in children with severe sepsis or septic shock?
In pediatric severe sepsis, left ventricular diastolic dysfunction defined by both E/e' and E/A was not associated with mechanical ventilation requirements, though an alternative definition using E/e' alone showed a significant association.
Answers are grounded in this paper and cite their sources.
LV diastolic dysfunction showed no association with outcomes in pediatric sepsis; leaves open its prognostic value for future prospective evaluation.
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Ginsburg et al. (2021) conducted a cohort in Severe sepsis and septic shock (n=204). Left ventricular diastolic dysfunction vs. No left ventricular diastolic dysfunction was evaluated on Requirement for invasive mechanical ventilation at the time of echocardiogram (difference in proportion +5%, 95% CI -8% to 17%, p=0.52). Left ventricular diastolic dysfunction was not significantly associated with requiring invasive mechanical ventilation at the time of echocardiogram (72% vs 67%; difference +5%; p=0.52).
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