Key result
Monitoring peak height and/or endogenous thrombin potential in platelet-free plasma with 1 pM tissue factor was the most sensitive method to detect hypercoagulability from elevated factor levels.
Population
In vitro plasma samples (corn trypsin inhibitor-treated platelet-free plasma and platelet-rich plasma)
Comparison
Varying assay conditions and elevated clotting… vs Different assay conditions compared against each…
Design
Preclinical
Authors
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Should not change clinical monitoring; hypothesis-generating for optimized CAT parameters in preclinical hypercoagulability models.
Calibrated automated thrombography using platelet-free plasma initiated with 1 pM tissue factor provides the highest sensitivity for detecting hypercoagulability from elevated procoagulant factors.
Machlus et al. (2009) studied Hypercoagulability. Assay conditions (tissue factor, thrombomodulin, platelets/lipids) was evaluated on Thrombin generation parameters (lag time, time to peak, peak height, endogenous thrombin potential). Monitoring peak height and/or endogenous thrombin potential in platelet-free plasma with 1 pM tissue factor was the most sensitive method to detect hypercoagulability from elevated factor levels.
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