What is the clinical evidence from this study?

Population: Healthy (n=10). Intervention: Various environmental conditions. Primary outcome: Behavior of the temperature of the toe in contrast to that of the finger.

What does this research mean for the field?

Environmental exposure to 20 °C and approximately 55% humidity five hours postprandially produces consistent, reliable, and reproducible toe temperature responses suitable for evaluating vasodilator drugs and procedures. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify specific environmental conditions that produce consistent and reproducible skin temperature responses in healthy human subjects for clinical testing.

August 9, 2026Circulation

Skin Temperature Response of Normal Human Subjects to Various Conditions

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Key result

Standardized temperature and humidity conditions yield reproducible toe vasodilation patterns for vasodilator drug testing.

n=10

Key Points

To identify specific environmental conditions that produce consistent and reproducible skin temperature responses in healthy human subjects for clinical testing.
Exposed 10 healthy volunteers (5 males and 5 females, aged 25–41 years) to multiple environmental conditions inside a constant-temperature chamber.
Evaluated peripheral skin temperature behavior in the toes and fingers under controlled ambient temperatures, humidity levels, and postprandial intervals.
Toe temperature responses exhibited consistent, reliable, and reproducible behavior at 20°C ambient temperature, approximately 55% relative humidity, and five hours post-meal, in contrast to finger temperature behavior.
Identified these cooler-than-standard environmental parameters as an optimal baseline setting for evaluating the efficacy of vasodilator drugs and clinical procedures.

Structured PICO

Population

10 healthy volunteers (50% female), aged 25 to 41 years, exposed to various environmental conditions.

Exposure

Exposure to environmental conditions of 20 C and about 55 per cent humidity, about five hours after the last meal

Outcome

Behavior of the temperature of the toe in contrast to that of the fingersurrogate

Discussion

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Implication

Specific environmental conditions (20 C, 55% humidity, fasting) produce reliable toe temperature responses suitable for testing vasodilator drugs.

Cite This Study

Redisch et al. (1952) studied Healthy (n=10). Various environmental conditions was evaluated on Behavior of the temperature of the toe in contrast to that of the finger. Exposure to 20 C and 55% humidity about five hours after a meal produced consistent and reproducible toe temperature behavior, suitable for testing vasodilator drugs.

synapsesocial.com/papers/6a78eeccb091e6fcb88f2bb3 https://doi.org/10.1161/01.cir.6.6.862

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Implication

Specific environmental conditions (20 C, 55% humidity, fasting) produce reliable toe temperature responses suitable for testing vasodilator drugs.

Skin Temperature Response of Normal Human Subjects to Various Conditions

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Skin Temperature Response of Normal Human Subjects to Various Conditions

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider