Key result
EnXtra® with or without caffeine significantly increased alertness and calmness scores compared to placebo (p < 0.001) with no significant changes in ECG or haemodynamic parameters (p > 0.05).
Why the study?
The study was conducted to evaluate the long-term safety and perceivable mental acuity benefits of EnXtra in healthy individuals.
Does EnXtra with or without caffeine improve mental acuity and maintain cardiovascular safety in healthy adults?
RCT
randomized
Does EnXtra with or without caffeine improve mental acuity and maintain cardiovascular safety in healthy adults?
EnXtra demonstrates psychostimulant efficacy by improving alertness and calmness without adverse cardiovascular effects over 12 weeks in healthy adults.
Answers are grounded in this paper and cite their sources.
Supports 12-week EnXtra use for alertness in healthy adults; extends cardiovascular safety data for this caffeine alternative.
Objective: The present randomized, placebo-controlled study aimed to assess the long-term safety and perceivable mental acuity benefits of EnXtra® in healthy individuals.Methods: Study participants were administered EnXtra® with or without caffeine for a period of 12 weeks. The cardiovascular safety was evaluated by assessing change in QT interval, blood pressure and heart rate. Further, other efficacy variables evaluated were change in perceived alertness and calmness by Bond and Lader mood scales, Sleep disturbance by Pittsburgh sleep quality Index and daytime sleepiness by Epworth sleepiness scale.Results: None of the study group showed any significant change in the ECG or haemodynamic parameters as compared to baseline (p > 0.05). Post consumption, alertness and calmness scores were significantly increased in the EnXtra®, and EnXtra® plus caffeine group (p < 0.001) as compared to placebo. Daytime sleep scores decreased in the EnXtra® group however change was not significant. Sleep quality remained undisturbed in all three arms.Conclusion: The findings demonstrated the psychostimulant efficacy of EnXtra® with no safety concerns on long-term usage.
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Srivastava et al. (2020) conducted an RCT in Healthy adults. EnXtra® with or without caffeine vs. placebo was evaluated on Change in QT interval, blood pressure, heart rate, and perceived alertness and calmness (p=<0.001). EnXtra® with or without caffeine significantly increased alertness and calmness scores compared to placebo (p < 0.001) with no significant changes in ECG or haemodynamic parameters (p > 0.05).
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