Natriuretic Peptide System Gene Variants Are Associated with Ventricular Dysfunction after Coronary Artery Bypass Grafting

1,164 men and women aged 20 to 89 years of European descent scheduled for isolated primary coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB). Exclusions included emergency surgery, preoperative inotrope/IABP/VAD support, severe renal dysfunction, and non-European ethnicity.

Presence of genotypic variants within the natriuretic peptide system genes (NPPA, NPPB, NPPC, NPR1, NPR2, NPR3, and CORIN)

Absence of the specific minor alleles/variants (wild-type genotypes)

Postoperative ventricular dysfunction (VnD), defined as a new requirement for two or more inotropes or new placement of an intraaortic balloon pump or ventricular assist device either intraoperatively after separation from CPB or postoperatively in the intensive care unitcomposite