November 16, 2004Circulation
Overexpression of Brain Natriuretic Peptide Facilitates Neutrophil Infiltration and Cardiac Matrix Metalloproteinase-9 Expression After Acute Myocardial Infarction
Why the study?
Does overexpression of brain natriuretic peptide facilitate neutrophil infiltration and MMP-9 expression after acute myocardial infarction in mice?
Population
Male BNP-transgenic mice and their nontransgenic littermates with acute myocardial infarction
Comparison
Overexpression of brain natriuretic peptide vs Nontransgenic (non-Tg) littermates
Design
Preclinical
Follow-up
3 days
Authors
Discussion
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Member takes
Implication
BNP overexpression may enhance early post-MI neutrophil influx and MMP-9 activity in mice; hypothesis-generating for remodeling, no clinical translation yet.
Structured PICO
Does overexpression of brain natriuretic peptide facilitate neutrophil infiltration and MMP-9 expression after acute myocardial infarction in mice?
P
Population
Male BNP-transgenic (BNP-Tg) mice and their nontransgenic (non-Tg) littermates with acute myocardial infarction
I
Intervention
Overexpression of brain natriuretic peptide (BNP-Tg)
C
Comparator
Nontransgenic (non-Tg) littermates
O
Outcome
Accumulation of neutrophils and expression and activation of matrix metalloproteinase (MMP)-9 in the ventriclessurrogate
Elevated plasma BNP facilitates neutrophil infiltration and increases MMP-9 activity in the infarcted area after acute MI, suggesting a key role in early extracellular matrix remodeling and wound healing.
Cite This Study
Kawakami et al. (2004) studied this question.