Key result
High 4-hour postoperative troponin-T levels (≥4 ng/ml) were significantly associated with a higher rate of short-term complications compared to levels <2 ng/ml (90.0% vs 37.8%).
Why the study?
The effectiveness of troponin for assessing cardiac tissue ischemia after pediatric open-heart surgery remains debated despite increasing demand for congenital heart surgeries.
Do high-sensitivity troponin T levels predict clinical outcomes and correlate with surgical variables in pediatric patients undergoing open-heart surgery for congenital heart disease?
Cohort (n=70)
No
Do high-sensitivity troponin T levels predict clinical outcomes and correlate with surgical variables in pediatric patients undergoing open-heart surgery for congenital heart disease?
Absolute Event Rate: 90% vs 37.8%
p-value: p=0.012
High-sensitivity troponin T levels measured 4 hours after pediatric open-heart surgery correlate with surgical duration and predict prolonged ICU/hospital stays and short-term complications.
Troponin T associations after pediatric open-heart surgery remain hypothesis-generating; leaves open prognostic utility pending larger validation.
Cardiac tissue ischemia can be assessed by a troponin biomarker in adults. However, its effectiveness after pediatric open-heart surgery is still being debated despite the increased demand for congenital heart surgeries. This study assesses the relationship of troponin T levels with many surgical, biochemical, and prognostic variables. This prospective, longitudinal study included 70 patients collected over one year. These patients underwent open-heart surgery and required a cardiopulmonary bypass machine at the Cardiac Center in Erbil, Iraq. Troponin T measurements were taken 4 times for each patient: the day before the operation, 4 and 24 hours post-surgery, and on the discharge day from the hospital. These measurements were correlated with many variables. The study revealed significantly higher troponin levels in children younger than three years old and in those with Fallot surgeries. Most patients with high 4-hour troponin levels developed short-term complications. Furthermore, significant correlations were observed between troponin levels with the duration of the whole operation and the durations of these specific procedures: cardiopulmonary bypass, aortic cross-clamp, and inotropic support. We also found that high troponin levels, particularly 4 hours post-surgery, can predict a longer-than-usual stay in the intensive care unit and hospital, as well as short-term complications
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Nadine A. Mahmood (2022) conducted a cohort in Congenital heart disease (n=70). High-sensitivity Troponin-T levels vs. Low Troponin-T levels was evaluated on Short-term complications (p=0.012). High 4-hour postoperative troponin-T levels (≥4 ng/ml) were significantly associated with a higher rate of short-term complications compared to levels <2 ng/ml (90.0% vs 37.8%).
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