Key result
Admission cTnI >~28 ng/ml predicts mortality after pediatric cardiac surgery.
Why the study?
There is a lack of procedure-specific data regarding postoperative troponin-I levels in infants undergoing cardiac surgery and their prognostic significance.
Does routine monitoring of cardiac troponin I concentrations within 24 hours of surgery predict postoperative mortality and morbidity in pediatric patients undergoing cardiopulmonary bypass surgery for congenital heart disease?
Cohort (n=103)
Yes
Does routine monitoring of cardiac troponin I concentrations within 24 hours of surgery predict postoperative mortality and morbidity in pediatric patients undergoing cardiopulmonary bypass surgery for congenital heart disease?
Effect estimate: AUC 0.725 (95% CI 0.629 - 0.809)
p-value: p=0.007
This study aims to evaluate the prognostic value of postoperative troponin I levels in pediatric patients undergoing congenital heart surgery, though no results are reported in the abstract.
Postoperative day-1 cTnI independently predicts inotrope duration and ICU stay; hypothesis-generating for risk stratification pending prospective validation.
Background: Troponin-I (TN-I) levels are elevated following pediatric cardiac surgery with speculation that particular patterns may have prognostic significance. There is lack of procedure-specific data regarding postoperative TN-I levels in infants undergoing cardiac surgery. Aim and objectives: the aim of the study was to assess the usefulness of routine monitoring of cardiac troponin I concentrations within 24 hours of surgery (cTn-I<24h) in neonates and infants undergoing cardiopulmonary bypass surgery. Also, correlate troponin I with postoperative mortality and morbidity in patients between one day and 15 years old who underwent cardiac surgery for congenital heart disease. Subjects and methods: This was a prospective randomized study in the period from April 2019 to November 2021, was conducted on 103 pediatric patients from Pediatric cardiac intensive care units in Abu El-Rish children's Hospital and Al-Nas hospital aging from one day old to 15 years old and had cardiopulmonary bypass surgery. Blood samples for troponin levels were taken from all patients in ICU on admission and 24 hours after operation.
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Ammar et al. (2022) conducted a cohort in Congenital heart disease (n=103). Elevated cardiac troponin I (cTn-I) levels vs. Lower cTn-I levels was evaluated on Mortality after ICU admission (AUC 0.725, 95% CI 0.629 - 0.809, p=0.007). Cardiac troponin I levels >27.9 ng/ml on admission significantly predicted mortality after pediatric cardiac surgery with an area under the curve of 0.725.
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