Key result
Children with ventricular septal defects and atrial septal defects had significantly higher serum cTnI levels compared to healthy children, indicating myocardial injury due to hemodynamic overload.
Why the study?
Does significant hemodynamic overload due to a left-to-right shunt (ASD or VSD) increase serum cTnI levels in children with congenital heart disease?
Population
412 clinically stable children, consisting of 30 children with atrial septal defect, 32 children with…
Design
Cohort
Authors
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Elevated cTnI may signal overload injury in pediatric ASD/VSD; hypothesis-generating, prospective validation needed before clinical adoption.
Cross-Sectional (n=412)
No
Does significant hemodynamic overload due to a left-to-right shunt (ASD or VSD) increase serum cTnI levels in children with congenital heart disease?
Absolute Event Rate: 0.029% vs 0%
p-value: p=<0.01
Highly sensitive cTnI assays can detect myocardial injury associated with volume and pressure overload in children with congenital heart disease, particularly those with VSD and pulmonary hypertension.
Sugimoto et al. (2011) conducted a cross-sectional in Congenital heart disease (Atrial and Ventricular Septal Defects) (n=412). Left-to-right shunt (ASD and VSD) vs. Healthy children was evaluated on Serum cardiac troponin I (cTnI) levels (p=<0.01). Children with ventricular septal defects and atrial septal defects had significantly higher serum cTnI levels compared to healthy children, indicating myocardial injury due to hemodynamic overload.
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