Why the study?
Do molecular assays for chromosomal translocations improve the differential diagnosis of pediatric soft tissue sarcomas compared to standard histopathologic and cytogenetic analysis?
Population
79 pediatric soft tissue sarcoma patients with frozen tumor tissue and histopathologic slides available for…
Comparison
Molecular assays for characteristic chromosomal… vs Standard histopathologic and cytogenetic analysis
Design
Cross-sectional, Blinded comparison
Authors
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Supports adjunctive RT-PCR in pediatric sarcomas; extends cytogenetic data but leaves open prospective validation before routine adoption.
Do molecular assays for chromosomal translocations improve the differential diagnosis of pediatric soft tissue sarcomas compared to standard histopathologic and cytogenetic analysis?
Molecular assays for specific gene fusions provide a rapid, objective, and sensitive genetic approach to the differential diagnosis of pediatric soft tissue sarcomas.
Frederic G. Barr (1995) studied this question.
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