What question did this study set out to answer?

To characterize the clinicopathological and immunohistochemical features of a distinct intra-abdominal small-cell tumor entity.

June 1, 1991The American Journal of Surgical Pathology

Intra-abdominal Desmoplastic Small Round-Cell Tumor

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Authors

WGWilliam L. GeraldUniversitat Autònoma de Barcelona HMHariatmi K. MillerCity Of Hope National Medical Center HBHector BattiforaYamamoto Hospital

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Implication

Case series describes an aggressive intra-abdominal malignancy in adolescent males, highlighting a distinct small round-cell tumor with unique multidirectional phenotypical differentiation.

Key Points

To characterize the clinicopathological and immunohistochemical features of a distinct intra-abdominal small-cell tumor entity.
Analyzed clinical presentation, gross pathology, histology, and outcomes in 19 patients presenting with distinctive small-cell neoplasms.
Performed comprehensive immunohistochemical profiling assessing epithelial, neural, and myogenic lineage markers.
Identified a strong predilection for adolescent males (mean age: 18.6 years) with primary intra-abdominal localization, nested growth patterns, and intense desmoplasia.
Demonstrated marked multidirectional differentiation with co-expression of epithelial (keratin, EMA), neural (NSE), and muscle (desmin) markers alongside highly aggressive behavior.

Cite This Study

Gerald et al. (1991) studied this question.

synapsesocial.com/papers/6a790e211ad0da1615674f43 https://doi.org/10.1097/00000478-199106000-00001

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Implication

Case series describes an aggressive intra-abdominal malignancy in adolescent males, highlighting a distinct small round-cell tumor with unique multidirectional phenotypical differentiation.

Intra-abdominal Desmoplastic Small Round-Cell Tumor

Discussion

Member takes

Implication

Key Points

Cite This Study

Intra-abdominal Desmoplastic Small Round-Cell Tumor

Discussion

Member takes

Implication

Key Points

Cite This Study

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