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The feasibility of using visible fluorimetry as a simple spectroscopic method for cancer diagnosis and/or management was investigated by recording the visible fluorescence emission spectra of sera from cancer patients and healthy individuals. Characteristic visible fluorescence emission spectra were found to occur in sera of some cancer patients, e.g., patients with breast or lung cancer, with spectral features similar to those observed among porphyrin and porphyrin-related compounds. Possible physico-chemical factors responsible for the occurrence of these unique visible fluorescence features among cancer patients were briefly discussed.
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Aiken et al. (1994) studied this question.
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