Key result
The presence of more than three components of metabolic syndrome increased the chance of kidney damage in elderly individuals.
Why the study?
Metabolic syndrome is a potential risk factor for chronic kidney disease in the elderly, but mechanisms and events in the relationship between kidney damage and metabolic syndrome remain controversial.
Are individual and combined components of metabolic syndrome associated with compromised glomerular filtration rate in elderly people?
Cross-Sectional (n=273)
Are individual and combined components of metabolic syndrome associated with compromised glomerular filtration rate in elderly people?
In elderly Brazilians, individual components of metabolic syndrome such as high triglycerides and LDL-c, as well as having more than three components, are associated with impaired renal function.
Answers are grounded in this paper and cite their sources.
MS may link to CKD in elderly; cross-sectional data leaves causality open for prospective trials.
Background: Current literature highlights that chronic kidney disease (CKD) is a public health problem and that metabolic syndrome (MS) is a potential risk factor, especially among the elderly population, since aging seems to create metabolic disorders such as hypertension, hypertriglyceridemia, and glycemic decompensation. Despite this, some mechanisms/events of the relationship between kidney damage and MS remain controversial. Objective: The objective of this study is to investigate the association of compromised glomerular filtration rate with metabolic syndrome and its components in a population of Brazilian elderly. Methods: This is a cross-sectional study carried out in Northeast Brazil with 273 elderly men and women aged between 60 and 93 years. Clinical, sociodemographic, anthropometric, and lifestyle data, as well as biochemical, blood pressure, and glomerular filtration rate variables, were evaluated. Data were analyzed using Stata® (Statacorp, College Station, Texas, USA), version 14, adopting a significance level of p<0.05. The research has ethical approval (no. 2,216,538). Results: There was a significant difference between impaired renal function and adequate values of WC (p = 0.044), triglycerides (p = 0.018), LDL-c (p = 0.015), and the presence of more than three components of MS (p = 0.036). High values of triglycerides (PR 1.48; p = 0.025) and LDLc (PR 1.44; p = 0.017) and presence of more than three components of MS (PR 1.45; p = 0.023) increase the chance of kidney damage. Conclusion: The presence of individual and combined components of MS (high triglycerides, cholesterol and LDL-c, and low HDL-c) promotes the impairment of renal function among the elderly studied. It is noteworthy that MS does not represent a significant independent factor to generate losses to GFR.
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Santos et al. (2022) conducted a cross-sectional in Metabolic syndrome and chronic kidney disease (n=273). Metabolic syndrome components vs. Absence of metabolic syndrome components was evaluated on Kidney damage (impaired renal function) (PR 1.45, p=0.023). The presence of more than three components of metabolic syndrome increased the chance of kidney damage in elderly individuals.
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